Product Code: 121020
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Frontline Combo can be used for the elimination of fleas and against new infestations of adult fleas for 4 week (for cats) and 8 weeks (for dogs), for the prevention of the multiplication of fleas by inhibiting the development of eggs, larvae and pupae originating from eggs laid by adult fleas for 6 weeks after application and the elimination of ticks for up to 2 weeks and biting lice. Frontline Combo Spot On can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD)

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Indications for use

For the treatment of dogs. To be used against infestations with fleas, alone or in association with ticks and/or biting lice.

Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 8 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for eight weeks after application.

Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus). The product has persistent acaricidal efficacy for up to 4 weeks against ticks.

Treatment of infestations with biting lice (Trichodectes canis).

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).


In the absence of available data, the product should not be used on puppies less than 8 weeks old.

Do not use in rabbits, as adverse reactions with even mortality could occur. In absence of studies, the use of the product is not recommended in non-target species.

Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.

This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for target species

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.

Dogs should not be allowed to swim in watercourses for 2 days after application.

Adverse reactions (frequency and seriousness)

Among the very rare suspected adverse reactions, transient skin reactions on the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use.

Use during pregnancy, lactation or lay

The product can be used during pregnancy and lactation.

Amounts to be administered and administration route

One pipette of 0.67 ml (S) per dog weighing over 2 and up to 10 kg,

One pipette of 1.34 ml (M) per dog weighing over 10 kg and up to 20 kg,

One pipette of 2.68 ml (L) per dog weighing over 20 kg and up to 40 kg,

One pipette of 4.02 ml (XL) per dog weighing over 40 kg

In the absence of safety studies the minimum treatment interval is 4 weeks.

Method of administration

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

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