ADVANTAGE Spot On Cat 4p

Product Code: 122001
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For the prevention and treatment of flea infestations on cats.

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Indications for use, specifying the target species

For the prevention and treatment of flea infestations on cats of less than 4 kg body weight.

For cats of 4 kg body weight and greater use Advantage® 80 for Cats

One treatment prevents further flea infestation for three to four weeks. The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) where this has been previously diagnosed by a veterinary surgeon. 


Do not treat unweaned kittens of less than 8 weeks of age.

Do not use in animals that are known to be hypersensitive to the active substance or any of the excipients. 

Adverse reactions (frequency and seriousness)

The product is bitter tasting and salivation may occa­sionally occur if the cat licks the application site immediately after treatment. This is not a sign of intoxication and disap­pears within some minutes without treatment (see also section 4.9 Amounts to be administered and administration route).

In very rare occasions skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation has also been reported. Excessive salivation and nervous signs such as incoordination, tremors and depression have been reported exceptionally in cats. 

Use during pregnancy, lactation or lay

No primary embryo­toxic, teratogenic or reproductive toxic effects have been observed during the studies with imidacloprid on rats and rabbits. Studies on pregnant and lactating queens together with their offspring are limited. Evidence so far suggests that no adverse effects are to be expected in these animals. 

Interaction with other medicinal products and other forms of interaction

No incompatibility has been observed between this product at twice the recommended dose and the following commonly used veterinary products: lufenuron, pyrantel and praziquantel. The compatibility of the product was also demonstrated with a wide range of routine treatments under field conditions including vaccination. 

Amounts to be administered and administration route

Dosage and Treatment Schedule


Cat (kg bw)


Number of Pipettes

(mg/kg bw)

< 4 kg

Advantage® 40 for Cats

1 x 0.4 ml

minimum of 10

4 kg

Advantage® 80 for Cats

1 x 0.8 ml

minimum of 10


Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developing stages is recommended. 

The product remains effective if the animal becomes wet, for example after exposure to heavy rain. However, re-treatment may become necessary, depending on the presence of fleas in the environ­ment. In these cases do not re-treat more frequently than once weekly.

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